Image: Dr. John Fagan

Curriculum Vitae

Dr. John Fagan

Dr. John Fagan is a leading authority on sustainability in the food and agricultural system, on biosafety, and on food safety and authenticity. He is a successful entrepreneur in the field of green biotechnology, having founded, built and sold Global ID Group (now FoodChain ID), a pioneering company developing innovative molecular biological tools to verify and advance food purity, safety and sustainability. His expertise is sought around the world by industry and government leaders, scientists, and the public, to whom he has presented hundreds of lectures and provided advisory services during the last decades.

Dr. Fagan is CEO and Chief Scientist of Health Research Institute (www.HRILabs.org) a 501(c)3 non-profit research, education and service institution dedicated to scientifically documenting the links between food production methods and food quality and nutrition. HRI applies cutting edge mass spectrometric and molecular biological approaches to assess the quality, nutrition, and authenticity of foods and to understand the impact of different agricultural practices on safety, quality and nutrition. By creating transparency regarding quality and nutrition, this work enables shoppers to make better food choices, which, in turn, drives market demand for the more nutritious foods produced organically without toxic agrochemicals or GMOs. 

Dr. Fagan is also Professor of Molecular Biology at Maharishi International University (www.miu.edu), where he leads a research program using transcriptomic and metabolomic approaches to understand the molecular biology of higher states of consciousness. He also contributes to the Regenerative Organic Agriculture program. Based on his personal experience of life-long Transcendental Meditation practice, he also contributes his time as a senior international administrator within the TM organization (www.tm.org). An important part of this work is the implementation of on-the-ground agricultural development projects that integrate the cutting edge of modern agricultural science with traditional and indigenous agricultural practices, preserving cultural integrity while maximizing food security at the farm and community levels.

Earlier Dr. Fagan conducted biomedical research, examining molecular mechanisms in carcinogenesis and cellular and gene-regulatory impacts of environmental toxicants such as dioxins. His research has been published in leading scientific journals and has been supported by millions of dollars in grants, including the prestigious National Institutes of Health Research Career Development Award. He earned his Ph.D. in molecular biology, biochemistry, and cell biology from Cornell University.


Education

1971—B.S., Cum Laude with Distinction in Chemistry, University of Washington, Seattle, WA

1977—Ph.D., Biochemistry, Molecular Biology & Cell Biology, Cornell University, Ithaca, NY

1980—Postdoctoral Training, Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD

Employment History

Non-Profit Sector

2015 – Present Chairman of the Board, CEO and Chief Scientist at Health Research Institute, a 501(c)3 non-profit research, education and service institution dedicated to understanding the links between food production methods, food quality, diet, and health and supporting the advancement of the food and agricultural system.

2009 – Present Founding Director Earth Open Source Institute, a non-profit dedicated to an open source, volunteer collaboration-based approach to aligning the food system with the self-sustaining laws of nature. Using open source collaboration, Earth Open Source engages people, communities, corporations, universities, and governments in achieving breakthrough advances to nourish humanity, increase equity, assure food security and preserve the Earth.

2012-2014 Founding Director ProTerra Foundation, a non-profit established in the Netherlands, which supports organizations at all levels of the agricultural value chain by providing effective tools for advancing their sustainability performance.

Private Sector

1996 - 2013 Founder and Chief Scientific Officer, Global ID Group, Inc. (now FoodChain ID, Inc.), which provides genetic testing, certification, and consulting services to governments and the food and agricultural industries and conducts basic research and development of new bioanalytical technologies. Subsidiaries: Genetic ID, Cert ID, and FoodChain ID.

1996-2012 Chairman of the Board, Global ID Group, Inc.

2002-2004 Chief Executive Officer, Genetic ID, Inc. and Cert ID, Inc.

Academic and Research Sector

1991-Present Professor of Molecular Biology, Maharishi University of Management
(Maharishi International University 1971-1995), Fairfield, IA

2015 - 2019 Dean, College of Sustainability, Maharishi University of Management

1985 - 2002 Chairman, Department of Chemistry, Maharishi University of Management

1985 - 2002 Co-Director, Physiology and Molecular and Cell Biology Ph. D. Program, Maharishi University of Management

1995 - 2002 Dean, Graduate School, Maharishi University of Management

1984 - 1991 Associate Professor of Molecular Biology, Maharishi University of Management

1980 - 1984 Group Leader, NIH Senior Staff Fellow, Gene Regulation Group, Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health

1977 - 1980 PHS Postdoctoral Fellow, 1977-1979 and NIH Staff Fellow, 1979-1980

Laboratory of Molecular Biology, National Cancer Institute, NIH

1971 - 1976 Pre-doctoral Research Assistant, Section of Biochemistry, Molecular & Cell Biology, Cornell Univ., Ithaca, NY

Expertise and experience

  • Leadership

    • As Founder, Chairman of the Board, Chief Scientific Officer, and sometime CEO, successfully led the expansion of Global ID Group (Genetic ID, Cert ID, and FoodChain ID) for nearly 18 years, during which it grew to around 125 employees in 5 offices and 3 laboratories on 4 continents, and was sold successfully in 2013.

  • Business development

    • Over an 18-year period, played a key roll in inspiring companies and governments on 5 continents to employ Global ID’s testing, certification and advisory services.

    • Worked for two decades with leaders in the corporate, governmental, and non-profit sectors to adopt practical standards for production and quality control of non-GMO products, organic products and products produced according to improved standards of environmental sustainability and social responsibility.

  • Communications

    • Writing skills range from development of consumer-oriented communication and marketing materials, at one extreme, to highly technical and scientific materials at the other, including the publication of peer-reviewed scientific publications.

    • Have delivered hundreds of presentations at conferences and other public, policy, industry, and scientific venues during the last 20+ years. Have also delivered hundreds of corporate presentations for both business development and for training purposes.

    • As the leader of Global ID, communicating the vision and inspiring the translation of that vision into enthusiastic action were key skills.

  • Multidisciplinary collaboration, cooperation and advisory

    • Because of the fundamental role of the food system in society, application of genetic modification technology to our food system has multiple and diverse dimensions and even more diverse impacts.

    • These GM food-related dimensions include: (a) science, (b) technology, (c) government policy, (d) industry policy and practices, (e) market and consumer trends.

    • Working at the intersection of these different dimensions, have advised governments, corporations and non-profits on GMO-related matters for two decades.

  • Research has resulted in:

    • Peer-reviewed research publications in the area of nutritional composition of crops and levels of functional biomolecules in medicinal herbs.

    • Peer reviewed research publications in the area of biosafety.

    • Peer-reviewed research publications in the area of GMO detection methods and standards.

    • Peer-reviewed research publications on biomedical research examining molecular mechanisms in carcinogenesis and assessing the cellular and gene-regulatory impacts of environmental toxicants such as dioxins and PCBs.

    • Peer-reviewed research publications on the molecular biology of higher states of consciousness and Transcendental Meditation and on practical benefits of Ayurveda, the traditional medical system of India.

  • Organic agriculture standards and certification

    • 22 years of experience in organic agriculture standards and certification.

    • Member of the Organic Materials Review Institute’s Advisory Council from 1998 to the present. Provide technical advice regarding suitability of inputs for organic agriculture.

    • Owned and operated the largest organic certification organization in Japan (ICS Japan) from 1998 until 2011.

    • Contributed to development of the International Standard for Maharishi Vedic Organic Agriculture.

  • Organic and Maharishi Vedic Organic Agricultural Development Projects

    • Lead Maharishi Vedic Organic and Organic agricultural projects in Nepal.

    • Contributed to Maharishi Vedic Organic Agricultural projects in USA, Brazil and India.

    • Provided research and advisory services to MVOA projects internationally.

    • Provided research, advisory and certification support to Organic agricultural projects internationally.

  • GMO analysis

    • Developed the first test for gene-edited GMOs

    • Pioneered the development of GMO testing, established the first GMO testing labs in the US and Japan and an early lab in Europe, licensed Genetic ID GMO testing technology to labs in 17 countries around the world.

    • Two decades of experience in analysis of GM food and agricultural products at all levels of the food chain from farm field to retail shelf.

    • Led the development of de novo tests for all GMOs that were released commercially or that entered the food system globally between 1996 and 2013.

Led the development of the sampling and monitoring systems required to effectively apply GMO testing methods to achieve food and agricultural quality control, quality assurance and certification objectives.

  • Certification, monitoring and quality control—Non-GMO, Sustainability and Organic

    • Two decades of experience in control, monitoring and certification related to presence/absence of GMOs in food and agricultural products at all levels of the food chain from farm field to retail shelf.

    • Central to this effort was the development and implementation of non-GMO certification programs.

    • These certification programs are highly structured and include the following: (a) quality assurance systems designed to maintain GMO content of products below specified action thresholds, (b) use of segregation, traceability and monitoring systems as key quality assurance elements, (c) independent verification of the effectiveness of the quality assurance system through third-party monitoring, including inspections, sampling, and testing, (d) transparent reporting of the results of the third-party independent monitoring process.

    • This expertise was also applied to develop or operate certification programs verifying compliance with organic standards and other standards for improved social responsibility and environmental sustainability in the food and agricultural system.

    • Specific certification programs:

      • 1997—Led the development and implementation of the first international non-GMO certification program, which is also the longest-lived and currently largest volume non-GMO certification program globally—Cert ID Non-GMO Certification. This grew by the early 2000’s to certification of volumes in excess of 5 million metric tons of non-GMO soy and soy derivatives (soy lecithin, soy protein isolate, soy meal, etc.) per year, mostly produced in Brazil and India for export to Europe.

      • 2004—Led the team that developed the ProTerra Certification Standard and Program, which verifies products as both non-GMO and produced according to improved standards of environmental sustainability and social responsibility. The scale of this program was 4 million metric tons per year in 2013. This program was operated in house by Cert ID until 2012. At that time, I led the team that founded the independent non-profit ProTerra Foundation and transferred the ProTerra Certification program to the foundation. I served as a director of the foundation until February 2014.

      • 2006—The Non-GMO Project is an industry-led non-profit. More than $15 billion in sales and 40,000 branded food products are currently verified/certified through this program in North America (see www.non-gmoproject.org). Operating through FoodChain Global Advisors, which served as the Technical Administrator for the Non-GMO Project product verification program, we played a key role in the inception of the program, in creating and developing the standard, in leading the set-up of the technical systems for the verification process, and the on-going high-level management of the technical administration of the certification / verification operation.

      • 1998 to 2011—Owned and operated the largest organic certification company in Japan.

  • Laboratory quality assurance and quality control

    • 22 years of experience in laboratory quality assurance and quality control according to ISO 24276 and ISO17025.

    • Was part of the ISO Technical Advisory Group that developed ISO 24276 (standards for methods of analysis of GMOs). We also used this standard, even before it was officially published, as one of several inputs for designing commercial GMO testing methods and protocols for use at Genetic ID.

    • Led the team that initially achieved accreditation of the US Genetic ID lab to ISO 17025 (accreditation of testing and calibration laboratories) in 1999 and led the achievement, and for more than 12 years, the maintenance, of ISO 17025 accreditation in the various Genetic ID laboratories. For another 6 years I was responsible for high-level management of accreditation.

    • Led the team that designed and implemented the quality assurance program for laboratories that licensed the Genetic ID GMO testing technology.

    • Led the team that provided training and consulting to numerous food and agriculture organizations aiming to establish identity preservation and traceability systems. This work focused particularly on maintaining the non-GMO integrity and the sustainability of their products. I have also trained and supervised several people in provision of such training and consulting.

  • Training and mentoring

    • For 12 years, took a direct role in managing the Genetic ID testing labs, including mentoring senior lab staff and supervising technical staff. For the subsequent 6 years, was responsible for mentoring and supervision of laboratory senior staff.

    • Led the teams that developed the in-house training program for technicians, which is used in all Genetic ID laboratories.

    • Genetic ID has licensed its GMO testing technology to laboratories in 17 countries around the world between 1997 and 2006. I conceived of the licensing program and led the team that developed and implemented the program and refined it over many years. Specific elements developed include the following:

      • Communication program to enable candidate labs to understand and appreciate the utility of the licensing program for GMO testing technology.

      • A program to guide licensee labs to upgrade their facilities and operating systems to meet basic requirements for effective GMO testing.

      • Training program for senior scientists who were to take responsibility for supervising GMO testing services in licensee laboratories.

      • Training program for technicians who were to carry out GMO analyses in licensee laboratories.

      • Training program for quality assurance in licensee GMO testing laboratories. Required for both supervisory and technical staff of licensee laboratories.

      • Quality assurance program for the licensees, in which all licensee laboratories were trained in quality assurance principles as applied to GMO testing and engaged in an on-going quality assurance program in which they were, among other things, required to test and report results for a series of QA samples on a quarterly basis.

  • Analytical method validation

    • 22 years of experience in validation of analytical methods.

    • For 12 years, as Chief Scientific Officer at Genetic ID, supervised the validation of all GMO testing methods.

    • Was also responsible for designing the validation protocols used.

    • For the subsequent 6 years I was responsible for high-level supervision of validation.

  • Academic teaching

    • Have taught both graduate and undergraduate courses in molecular biology, biochemistry, cell biology as well as undergraduate general biology.

    • Have served as major professor/dissertation advisor for 12+ Ph.D. students.

Research Funding History

1986-1994 Research Grant (RO1), Cytochrome P450 Gene Structure and Regulation, National Cancer Institute, NIH Grant was renewed in 1986 for 5 years and again in 1994 for 3 years. I voluntarily returned this grant in November 1994 to publicly express concern regarding national research priorities that foster potential misuses of genetic engineering in medicine and in agriculture.

1991-1995 Research Career Development Award (KO4), Carcinogen Metabolizing P450s—Gene Regulation, National Cancer Institute, NIH

Patents

US 7,211,444, May, 2007, Waveguide and Assay, John Fagan

US 7,138,506 B2, Nov., 2006, Universal Microarray System, John Fagan

Recognition and Honors

1980-1984 National Institutes of Health Senior Staff Fellow, NIH

1979-1980 NIH Staff Fellow, NIH

1977-1979 Public Health Service Postdoctoral Fellow, NIH

1971-1979 NIH Pre-doctoral Trainee, Cornell University

Advisory Boards and Committees

1998-Present Advisory Council, Organic Materials Review Institute

2014-Present Non-GMO Supply Working Group (convened by Green America)

2011-2014 Board of Directors, ProTerra Foundation

2010-2015 American National Standards Institute—Sustainable Agriculture Standards Development Committee

2010-2013 Scientific Advisor to the Non-GMO Project Board

2006-2010 Non-GMO Project Board of Directors

1999-2003 Biotechnology Working Group, Organic Trade Association

1999-2002 Biotechnology Working Group, International Federation of Organic Agriculture Movements (IFOAM)

1993-2000 Editorial Advisory Board, The Biochemical Journal

1994 Ad Hoc Member, Chemical Pathology Study Section, National Institutes of Health

Scholarly Publications

55. Wenuganen, S.;Walton, K.G.; Katta, S.; Dalgard, C.L.; Sukumar, G.; Starr, J.; Travis, F.T.; Wallace, R.K.; Morehead, P.; Lonsdorf, N.K.; et al. Transcriptomics of Long-Term Meditation Practice: Evidence for Prevention or Reversal of Stress Effects Harmful to Health. Medicina 2021, 57, 218. https://doi.org/10.3390/medicina57030218

54. Chhalliyil, P., Ilves, H., Kazakov, S.A., Howard, S.J., Johnston, B.H., Fagan, J., 2020. A Real-Time Quantitative PCR Method Specific for Detection and Quantification of the First Commercialized Genome-Edited Plant. Foods 9, 1245. https://doi.org/10.3390/foods9091245

53. Velamuri, R., Sharma, Y., Fagan, J., Schaefer, J., 2020. Application of UHPLC-ESI-QTOF-MS in Phytochemical Profiling of Sage (Salvia officinalis) and Rosemary (Rosmarinus officinalis). Planta Medica International Open 07, e133–e144. https://doi.org/10.1055/a-1272-2903 

52. Fagan, J., Bohlen, L., Patton, S., Klein, K., 2020. Organic diet intervention significantly reduces urinary glyphosate levels in U.S. children and adults. Environmental Research 109898. https://doi.org/10.1016/j.envres.2020.109898 

51. Sharma, Y., Fagan, J., Schaefer, J., 2020. In Vitro Screening for Acetylcholinesterase Inhibition and Antioxidant Potential in Different Extracts of Sage (Salvia officinalis L.) and Rosemary (Rosmarinus officinalis< L.). Journal of Biologically Active Products from Nature 10, 59–69. https://doi.org/10.1080/22311866.2020.1729239 

50. Sharma, Y., Schaefer, J., Streicher, C., Stimson, J., Fagan, J., 2020. Qualitative Analysis of Essential Oil from French and Italian Varieties of Rosemary ( Rosmarinus officinalis L.) Grown in the Midwestern United States. Analytical Chemistry Letters 10, 104–112. https://doi.org/10.1080/22297928.2020.1720805

49. Sharma, Y., Velamuri, R., Fagan, J., Schaefer, J., 2020. UHPLC-ESI-QTOF-Mass Spectrometric Assessment of the Polyphenolic Content of Salvia officinalis to Evaluate the Efficiency of Traditional Herbal Extraction Procedures. Rev. Bras. Farmacogn. https://doi.org/10.1007/s43450-020-00106-5 

48. Sharma, Y., Velamuri, R., Fagan, J., Schaefer, J., Streicher, C., Stimson, J., 2020. Identification and characterization of polyphenols and volatile terpenoid compounds in different extracts of garden sage (Salvia officinalis L.). Phcog Res 12, 149. https://doi.org/10.4103/pr.pr_92_19 

47. Sharma, Y., Fagan, J., Schaefer, J., 2019. Influence of organic pre-sowing seed treatments on germination and growth of rosemary (Rosmarinus officinalis L.). Biological Agriculture & Horticulture 0, 1–9. https://doi.org/10.1080/01448765.2019.1649193 

46. Paul J. Mills, Izabela Kania-Korwel,  John Fagan, Linda K. McEvoy, Gail A. Laughlin, Elizabeth Barrett-Connor, MD.: Journal of the American Medical Association. 318(16):1610-1611, 2017. doi:10.1001/jama.2017.11726 .

45. V. A. Shiva Ayyadurai, Michael Hansen, John Fagan, Prabhakar Deonikar.: In-Silico Analysis & In-Vivo Results Concur on Glutathione Depletion in Glyphosate Resistant GMO Soy, Advancing a Systems Biology Framework for Safety Assessment of GMOs. Journal of Plant Sciences 07(12):1571-1589, 2016. 

44. John Fagan, Terje Traavik and Thomas Bøhn.: The Seralini affair: degeneration of Science to Re-Science? Environ Sci Eur. 27:19, 2015. DOI 10.1186/s12302-015-0049-2

43. Shanthi Duraimani, Robert H. Schneider, Otelio S. Randall, Sanford I. Nidich, Shichen Xu, Muluemebet Ketete, Maxwell A. Rainforth, Carolyn Gaylord-King, John W. Salerno, John Fagan. Effects of Lifestyle Modification on Telomerase Gene Expression in Hypertensive Patients: A Pilot Trial of Stress Reduction and Health Education Programs in African Americans. PLoS ONE 10(11): e0142689, 2015. DOI: 10.1371/journal.pone.0142689 

42. Bøhn, T., Cuhra, M., Traavik, T., Sanden, M., Fagan,, J., Primicerio, R.: Compositional differences in soybeans on the market: Glyphosate accumulates in Roundup Ready GM soybeans. Food Chemistry 153: 207–215, 2014. http://dx.doi.org/10.1016/j.foodchem.2013.12.054

41. Antoniou, M., Habib, M.E.M., Howard, C.V., Jennings, R.C., Leifert, C., Nodari, R.O., Robinson, C.J., and Fagan, J.: Teratogenic Effects of Glyphosate-Based Herbicides: Divergence of Regulatory Decisions from Scientific Evidence. J Environ Anal Toxicol S4:006. doi:10.4172/2161-0525.S4-006

40. Fagan, J.: Certification for a Sustainable World (Boomsma, M. and Mangnus, E. Editors), KIT (Royal Tropical Institute) Press, Amsterdam, The Netherlands, From Tropical Root to Responsible Food—Enhancing Sustainability in the Spice Trade, 2011.

39. Quirasco, M., Schoel, B., Chhalliyil P., Fagan J., and Gálvez A.: Real-time and conventional PCR detection of Liberty Link® rice varieties and transgenic soy in rice sampled in the Mexican and American retail markets. Analytical & Bioanalytical Chemistry 392: 395-404, 2008.

38. Fagan, J.: Monitoring GMOs Released into the Environment and the Food Production System (Traavik, T. & Lim, L.C. Editors), Tapir Academic Press, Trondheim, Biosafety First, 2007.

37. Quirasco, M., Schoel, B., Plasencia, J., Fagan, J. and Galvez, A.: Suitability of Real-Time Quantitative Polymerase Chain Reaction and Enzyme-Linked Immunosorbent Assay for cry9C Detection in Mexican Corn Tortillas: Fate of DNA and Protein After Alkaline Cooking. J. AOAC International 87: 639-646, 2004.

36. Fagan, J.: Detection and Quantification of Genetically Modified Organisms in food by DNA-Based and Protein-Based Methods (Nollet, L.M.L. Editor), Marcel Dekker, Inc., Handbook of Food Analysis, 2nd Edition, Expanded and Revised, 2003.

35. Fagan, J.: DNA-Based Methods for Detection and Quantification of GMOs, Chapter in Testing of Genetically Modified Organisms in Food (F. Ahmed, Editor), Howarth Press, Binghamton, NY, 2004.

34. Fagan, J.: Cert ID a Successful Example of an Independent, Third Party Certification System, USDA Economic Research Service and Farm Foundation monograph in preparation, currently available on Farm Foundation website: http://www.farmfoundation.org/projects/documents/Fagan.pdf, 2003.

33. Fagan, J.: Detecting DNA from Genetically Modified Plants. In Dealing with Genetically Modified Crops (Eds. Wilson, R.F., Hou, C.T., and Hildebrand, D.F.), AOCS Press, Champaign, ISBN: 1-893997-22-7. Chapter 13, pp. 115-131, 2001.

32. Fagan, J.: Genetically Modified Organisms. Facilitation of Industry Response to consumer Demands and Government Regulations. In Biotechnology International III, Special Millennium Issue: The Biotech Millennium (Ed. Alizadeh, B.N.), Thomas Laszlo Press, ISSN: 1094-9984. 2001.

31. Fagan, J., Schoel, B., Haegert, A., Moore, J. and Beeby, J.: Performance Assessment under Field Conditions of a Rapid Immunological Test for Transgenic Soybeans. International Journal of Food Science and Technology 36: 357-367, 2001.

30. Luo, B., Perry, D.J., Zhang, L., Kharat, I., Basic, M. and Fagan, J.B.: Mapping Sequence Specific DNA-Protein Interactions: A Versatile, quantitative Method and Its application to Transcription Factor XF1. Journal of Molecular Biology  266: 479-492, 1997.

29. Barker, C., Fagan, J. B. and Pasco, D.S.:  Down-regulation of P4501A1 and P4501A2 mRNA expression in isolated hepatocytes by oxidative stress. Journal of Biological Chemistry  269: 3985-3990, 1994.

28. Reick, M., Robertson, R.W., Pasco, D.S. and Fagan, J.B.:  Down-regulation of nuclear arylhydrocarbon receptor DNA-binding and transactivation functions: requirement for a labile or inducible factor.  Molecular and Cellular Biology  14: 5653-5660, 1994.

27. Robertson, R.W., Zhang, L., Pasco, D.S., and Fagan, J.B.:  Aryl hydrocarbon-induced interactions at multiple DNA elements of diverse sequence—a multicomponent mechanism for activation of cytochrome P4501A1 (CYP1A1) gene transcription.  Nucleic Acids Research, 22: 1741-1749, 1994.

26. Pasco, D.S, Boyum, K.W., Elbi, C., Siu, C.S., and Fagan, J.B.:  Inducer-dependent transcriptional activation of the P4501A2 gene in vivo and in isolated hepatocytes. Journal of Biological Chemistry  268: 1053-1057, 1993.

24. Saatcioglu, F., Perry, D.J., Pasco, D.S., and Fagan, J.B.:  Multiple DNA-binding factors interact with overlapping specificities at the aryl hydrocarbon response element of the cytochrome P450IA1 gene.  Molecular  and Cellular Biology  10: 6408-6416, 1990.

25. Barker, C., Fagan, J. B. and Pasco, D. S.:  Interleukin-1b suppresses the induction of P4501A1 and P4501A2 mRNAs in isolated hepatocytes.  Journal of Biological Chemistry 267: 8050-8055, 1992.

23. Saatcioglu, F., Perry, D.J., Pasco, D.S. and Fagan, J.B.:  Aryl hydrocarbon (Ah) receptor DNA-binding activity--sequence specificity and Zn2+ requirement.  Journal of Biological Chemistry  265: 9251-9258, 1990.

22. Pasco, D.S. and Fagan, J.B.:   Efficient DNA-mediated gene transfer into primary cultures of adult rat hepatocytes. DNA  8: 535-541, 1989.

21. Teifeld, R.M., Fagan, J.B. and Pasco D.S.: Transient superinducibility of cytochrome P450c (CYP1A1) mRNA and transcription.  DNA  8: 329-338, 1989. 

20. Pasco, D.S., Boyum, K.W., Merchant, S.N., Chalberg, S.C., and Fagan, J.B.  Transcriptional and post-transcriptional regulation of the genes encoding cytochromes P-450c and P-450d in vivo and in primary hepatocyte cultures.  Journal of Biological Chemistry  263: 8671-8676, 1988.

19. Einck, L., Fagan, J. and Bustin, M.: Chromatin structure of the cytochrome P-450c gene changes following induction.  Biochemistry  25: 7062-7068, 1986.

18. Fagan, J.B., Pastewka, J.V., Chalberg, S.C., Gozukara, E.M., Guengerich, P.F. and Gelboin, H.V.: Non-coordinate regulation of the mRNAs encoding cytochromes P-450BNF/MC-B P-450ISF/BNF-G.  Archives of Biochemistry and Biophysics  244: 261-272, 1986.

17. Steward, A.R., Wrighton, S.A., Pasco, D.S., Fagan, J.B., Li, D., and Guzelian, P.S.:  Synthesis and degradation of 3-methylcholanthrene-inducible cytochromes P-450 and their mRNAs in primary monolayer cultures of adult rat hepatocytes.  Archives of Biochemistry and Biophysics  241: 494-508, 1985.

16. Einck, L., Fagan, J.B., Bustin, M.:  The chromatin structure of a 3-methylcholanthrene induced cytochrome P-450 gene.  Biochemistry  24: 5269-5276, 1985.

15. Protic-Sabljic M., Whyte, D., Fagan, J.B., Howard, B., Gorman, C.M., Padmanabhan, R. and Kraemer, K.H.:  Quantification of expression of linked cloned genes in an SV40 transformed xeroderma pigmentosum cell line. Molecular  and Cellular Biology  5: 1685-1693, 1985.

14. Gozukara, E.M., Fagan, J.B., Pastewka, J.V., Guengerich, P.F. and Gelboin, H.V.: Induction of cytochrome P-450 mRNAs quantitated by in vitro translation and immunoprecipitation.  Archives of Biochemistry and Biophysics  232: 660-669, 1984.

13. Protic-Sabljic, M., Fagan, J.B., and Kraemer, K.H.:  Transformation of xeroderma pigmentosum cells with cloned DNA.  In Cellular Responses to DNA Damage  (Eds. Friedberg, E.C. and Bridges, B.A.) pp. 647-656, 1983.

12. Fagan, J.B., Pastewka, J.V., Guengerich, P.F. and Gelboin, H.V.: Multiple cytochromes P-450 are translated from multiple mRNAs.  Biochemistry  22: 1927-1934, 1983.

11. Fagan, J.B., Pastewka, J.V., Park, S.S., Guengerich, P.F. and Gelboin, H.V.: Identification and quantitation of a 2.0 kilobase mRNA coding for 3-methylcholanthrene-induced cytochrome P-450 using cloned cytochrome P-450 cDNA.  Biochemistry  2l: 6574-6580, 1982.

10. Bustin, M., Neihart, N.K. and Fagan, J.B.: mRNA of Chromosomal proteins HMG-1 and HMG-2 are polyadenylated.  Biochemical and Biophysical Research Communications  101: 893-897, 1981.

9. Fagan, J.B., Park, S.S., Pastewka, J.V., Guengerich, P.F. and Gelboin, H.V.: DNA cloning and monoclonal antibodies:  Analysis of cytochrome P-450 regulation and function.  In Microsomes, Drug Oxidations and Drug Toxicity  (Eds. R. Sato and R. Kato) pp. 597-604.  Japan Scientific Societies Press, Tokyo (Wiley Interscience, NY), 1981.

8. Fagan, J.B., Sobel, M.E., Yamada, K.M., de Crombrugghe, B., and Pastan, I.: Effects of transformation on fibronectin gene expression using cloned fibronectin cDNA.  Journal of Biological Chemistry  256: 520-525, 1981.

7. Fagan, J.B., de Crombrugghe, B. and Pastan, I.:  Sequence rearrangement and duplication during synthesis of double stranded fibronectin cDNA catalyzed by AMV reverse transcription and Escherichia coli DNA polymerase I.  Nucleic Acids Research  8: 3055-3064, 1980.

6. Yamamoto, T., Sivaswami-Tyagi, J., Fagan, J.B., Jay, G., de Crombrugghe, B.,and Pastan, I.:  Molecular mechanism for the capture and excision of the transforming gene of avian sarcoma virus as suggested by analysis of recombinant clones. Journal of Virology  35: 436-443, 1980. 

5. Fagan, J.B., Yamada, K.M., de Crombrugghe, B., and Pastan, I.:  Partial purification and characterization of the messenger RNA for cell fibronectin. Nucleic Acids Research  6: 3471-3480, l979. 

4. Fagan, J.B. and Racker, E.:  The Determinants of Glycolysis in Normal and Transformed Chick Embryo Fibroblasts.  Cancer Research  38: 749-758, 1978.

3. Fagan, J.B. and Racker, E.:  Inhibition of (Na+-K+)-ATPase by Mg+2, ATP and K+. Biochemistry 16 152-158, 1977.

2. Fagan, J.B.: The determinants of glycolytic rate in normal and transformed chick embryo fibroblasts.  Doctoral Dissertation, Cornell University, 1977.

1. McCarty, R. and Fagan, J.B.:  Light-stimulated incorporation of N-ethylmaleimide into coupling factor 1 in spinach chloroplasts.  Biochemistry  12: 1503-1507, 1973.